SA's IVF Leader Since 1982
Treatments & Services

Recurrent Implantation Failure

Recurrent implantation failure (RIF) is a clinical condition where embryo implantation fails over multiple IVF/ICSI treatment cycles. It is typically defined by at least three previous embryo transfers of high-quality embryos without a confirmed pregnancy. This can be very demotivating and stressful for couples trying to get pregnant.

The RIF Clinic at Flinders Fertility, established by our Medical Director, Prof. Neil Johnson and Clinical Director, Assoc. Prof. Toby Angstmann, is dedicated to the diagnosis and treatment of the causes of implantation failure. Our goal is to increase the chances of a successful pregnancy through a thorough assessment and individual treatment plan.

Investigating the Causes of RIF

RIF can be due to numerous factors, and we take a comprehensive approach to identify the causes. Some of the tests we can perform include;

1. Embryo Quality Assessment:

  • Testing of embryos before transfer, including Preimplantation Genetic Testing for aneuploidy to confirm that the embryos have the right number of chromosomes.
  • The assessment of embryo development in the culture medium to improve the conditions for embryo culture.

2. Uterine and Endometrial Evaluation

  • 3D Ultrasound & Hysteroscopy to look for polyps, fibroids or adhesions in the uterus.
  • Endometrial Receptivity Analysis (ERA) to determine the best time to transfer embryo.
  • Endometrial Chronic Inflammation Testing to check for inflammation or infection that may prevent implantation.

3. Immune and Blood Clotting Factors

  • Natural Killer (NK) Cell Testing to check the immune response that could be hindering implantation.
  • Thrombophilia Screening to check for clotting disorders that may affect blood supply to the uterus.

4. Hormonal and Metabolic Assessments

  • To exclude thyroid dysfunction, Thyroid Function Tests will be done.
  • Insulin Resistance and PCOS Screening as metabolic disorders can affect implantation success.

5. Sperm Quality Investigations

  • DNA Fragmentation Analysis to determine the health of the sperm and how it can affect embryo formation.
  • Other semen tests which may help identify other male factor issues that may have been overlooked.

Personal Treatment Plan

After a thorough assessment, your fertility specialist will develop a tailored treatment strategy that may include:

  • Adjusting IVF protocols for improved embryo selection, immunotherapy or anti-inflammatory treatments to regulate immune responses.
  • Endometrial preparation techniques to optimise receptivity.
  • Lifestyle modifications and nutritional guidance.
  • Innovative techniques such as Embryo Glue.

If you have experienced repeated implantation failures and want a deeper investigation into possible causes, our RIF Clinic at Flinders Fertility is here to help.

Want to find out more?

For more information, book an appointment. Please mention that you are booking a recurrent implantation failure appointment to ensure that the appropriate consultation is selected.

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Frequently Asked Questions

RIF refers to the failure of embryos to implant, meaning a pregnancy never begins. Recurrent pregnancy loss occurs when pregnancies are achieved but do not progress beyond the early stages. Both conditions require different investigations and treatments.

Not necessarily. The first step is identifying the cause of RIF. In some cases, we may recommend treatments to improve implantation before attempting another cycle. If an IVF cycle is needed, we will optimise your treatment plan to increase your chances of success.

The timeframe depends on the number of tests required. Most patients complete the investigation within one to two months, allowing time to plan the next steps accordingly.

Yes, depending on the underlying cause. If the issue is related to hormonal imbalances, immune dysfunction, or uterine factors, targeted treatments may enhance fertility and improve the likelihood of both natural conception and IVF success.

Some tests and treatments may be eligible for Medicare rebates or private health insurance coverage. Our finance team can provide guidance on costs and rebates specific to your situation.